PVD News

Click on any of the articles below for the latest from the PVD community.

African-Americans Face Higher Risks of Diabetes and PAD, More Susceptible to Preventable Amputations

September 28, 2021


African-American people are at higher risk for diabetes and peripheral arterial disease (PAD), which combined make them more susceptible to preventable amputations. African-Americans are, statistically, twice as likely as non-Hispanic whites to have PAD. At the same time, one in four older African-American has diabetes.

Spotlight on Racial and Ethnic Disparities in Cardiovascular Disease

August 25, 2021


Cardiovascular diseases (CVD), principally ischemic heart disease and stroke, are the leading cause of death in the United States. Although management of CVD has led to improved mortality over the years, striking disparities in outcomes have persisted and widened among racial and ethnic groups. These disparities segregate along the lines of race and ethnicity, socioeconomic status, and geography. Health disparities, as defined by the World Health Organization, are “systematic, socially produced (and therefore modifiable) and unfair” conditions that dis...

Geographic and Socioeconomic Disparities in Major Lower Extremity Amputation Rates in Metropolitan Areas

August 25, 2021


Background: Rates of major lower extremity amputation in patients with peripheral artery disease are higher in rural communities with markers of low socioeconomic status, but most Americans live in metropolitan areas. Whether amputation rates vary within US metropolitan areas is unclear, as are characteristics of high amputation rate urban communities.

FDA Approves Expanded Peripheral Artery Disease (PAD) Indication for XARELTO® (rivaroxaban) Plus Aspirin to Include Patients After Lower-Extremity Revascularization (LER) Due to Symptomatic P

August 24, 2021


XARELTO® is the only anticoagulant in 20 years to show significant benefit in patients with PAD who remain at high risk for major thrombotic events, including acute limb ischemia and amputation. PAD impacts 20 million Americans and is the leading cause of amputations in the U.S., with rates continuing to rise.

Exercise, Medication and Diet Changes Key to Treating High Cholesterol

August 24, 2021


High levels of lipids (fats) in the blood, including cholesterol and triglycerides, is also called "hyperlipidemia."

Hyperlipidemia can lead to your blood vessels getting blocked with fatty deposits, limiting blood flow. This condition also increases your risk of developing cardiovascular disease, affecting blood vessels supplying the heart (coronary artery disease), brain (cerebrovascular disease) and arms and legs (peripheral artery disease).

Creation of a vascular inducing device using mesenchymal stem cells to induce angiogenesis

July 26, 2021


Abstract: Conventional treatments of peripheral vascular disease and coronary artery disease have partial success but are still limited. Methods to deliver angiogenic factors into ischemic areas using gene, protein and cell therapies are faced with difficult issues such a delivery, effective concentration and duration of action. Tissue engineering offers the possibility of creating a functional self-contained three-dimensional (3D) unit that works as a coordinated biological pump that can secrete a whole range of angiogenic factors. We report a tissue e...

Influence of pedal arch quality on 5-year survival and limb salvage in patients with diabetic foot ulcers undergoing peripheral angiography

July 13, 2021


Introduction: The aim of this study was to evaluate the influence of pedal arch quality on 5-year survival and limb salvage in diabetic patients with foot wounds undergoing peripheral angiography.

First report of intravascular ultrasound-guided intravascular lithotripsy to treat an underexpanded stent in the superficial femoral artery

July 13, 2021


Background/objective: To evaluate the safety and utility of a new in Europe intravascular ultrasound (IVUS) catheter in a case of peripheral arterial disease caused by in-stent restenosis of the superficial femoral artery.

Inflammation and its associations with aortic stiffness, coronary artery disease and peripheral artery disease in different ethnic groups: The HELIUS Study

July 7, 2021


Background: Evidence shows important ethnic differences in vascular dysfunction rates; however, the mechanisms driving these differences remain unclear. One potential factor is the ethnic differences in the role of inflammation in vascular injury. We tested the hypothesis that low-grade inflammation is unequally associated with vascular dysfunction in different ethnic groups.

Peripheral Artery Disease and Abdominal Aortic Aneurysm: The Forgotten Diseases in COVID-19 Pandemic. Results from an Observational Study on Real-World Management

July 6, 2021


It is well established that patients with peripheral artery disease (PAD) as well abdominal aortic aneurysm (AAA) have an increased cardiovascular (CV) mortality. Despite this higher risk, PAD and AAA patients are often suboptimality treated. This study assessed the CV profile of PAD and AAA patients, quantifying the survival benefits of target-based risk-factors modification even in light of the COVID-19 pandemic.


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